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Here's what research had to say about Psilocybin Therapy in 2022

Most cited journal articles on Psilocybin Therapy published in 2022

Psilocybin therapy refers to the use of psilocybin, a psychoactive compound found in certain species of mushrooms, in a therapeutic setting to treat mental health conditions such as depression, anxiety, PTSD, and addiction.

Research on psilocybin therapy has shown that it has potential therapeutic benefits, but it is still in the early stages of research. Studies have found that psilocybin therapy can lead to significant reductions in symptoms of depression and anxiety, as well as improvements in measures of well-being and quality of life.

Research has also shown that psilocybin therapy can be effective in treating treatment-resistant conditions such as depression and PTSD and that it can help people to quit smoking, alcohol, and other substance abuse.

Research has also shown that the therapeutic effects of psilocybin are likely related to its ability to promote neuroplasticity, which is the ability of the brain to change and adapt in response to new experiences. Psilocybin therapy has also been found to increase brain-derived neurotrophic factor (BDNF) which is a protein that helps to support the growth and survival of neurons.

Research is ongoing to understand the mechanisms by which psilocybin therapy works, as well as the best ways to administer and regulate it for therapeutic use. Researchers are also working to understand the long-term effects of psilocybin therapy and how to minimize any potential risks.

It is worth noting that psilocybin is currently a Schedule I controlled substance, meaning it is illegal to possess, use, or distribute it in the United States. However, some cities and states have decriminalized the possession of small amounts of psilocybin, and some research is being done under the "compassionate use" exemption.

DOI: 10.1038/s41591-022-01744-z
2022
Cited 46 times
Increased global integration in the brain after psilocybin therapy for depression
Richard E. Daws, Christopher Timmermann, Bruna Giribaldi, James D Sexton, Matthew B Wall, David Erritzoe, Leor Roseman, David J. Nutt, Robin Carhart-Harris
Psilocybin
Escitalopram
Antidepressant
DOI: 10.1001/jamapsychiatry.2022.2096
2022
Cited 30 times
Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder
Michael P. Bogenschutz, Stephen L. Ross, Snehal Bhatt, Tara Baron, Alyssa A. Forcehimes, Eugene M. Laska, Sarah E. Mennenga, Kerry O'Donnell, Lindsey T. Owens, Samantha K. Podrebarac, John Rotrosen, J. Scott Tonigan, Lindsay Worth
Psilocybin
Placebo
Diphenhydramine
DOI: 10.1177/02698811211073759
2022
Cited 29 times
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
Natalie Gukasyan, Alan K. Davis, Frederick S. Barrett, Mary P Cosimano, Nathan D. Sepeda, Matthew W. Johnson, Roland R. Griffiths
Psilocybin
Hamd
Psychology
DOI: 10.1038/s41386-022-01297-2
2022
Cited 16 times
Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects
Felix Müller, Laura Ley, Anna M. Becker, Isabelle Straumann, Patrick Vizeli, Sebastian Silva Kuehne, Marc A Roder, Urs Duthaler, Karolina E. Kolaczynska, Nimmy Varghese, Anne Eckert, Matthias E. Liechti
Psilocybin
Lysergic acid diethylamide
Hallucinogen
DOI: 10.3389/fphar.2021.788155
2022
Cited 11 times
Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression
Roberta Murphy, Hannes Kettner, Rick Zeifman, Bruna Giribaldi, Laura Kartner, Jonny Martell, Tim R H Read, Ashleigh Murphy-Beiner, Michelle Baker-Jones, David J. Nutt, David Erritzoe, Rosalind Watts, Robin L. Carhart-Harris
Escitalopram
Psilocybin
Psychology
DOI: 10.1016/j.funbio.2022.01.003
2022
Cited 10 times
Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development
R.C. Van Court, M.S. Wiseman, K.W. Meyer, D.J. Ballhorn, Kevin R. Amses, Jason C. Slot, Bryn T. M. Dentinger, R. Garibay-Orijel, J.K. Uehling
Psilocybin
Biology
Diversity (politics)
DOI: 10.1016/j.drugpo.2021.103473
2022
Cited 7 times
United States National Institutes of Health grant funding for psychedelic-assisted therapy clinical trials from 2006–2020
Brian S. Barnett, Sloane E. Parker, J. Weleff
Psilocybin
Clinical trial
Medicine
DOI: 10.1016/j.pharmthera.2022.108195
2022
Cited 7 times
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation
Sanket B. Raut, Padmaja A. Marathe, Liza van Eijk, Rajaraman Eri, Manoj Ravindran, David M. Benedek, Robert J. Ursano, Juan J. Canales, Luke R. Johnson
MDMA
Paroxetine
Psilocybin
DOI: 10.1016/j.jpainsymman.2022.01.024
2022
Cited 5 times
The Therapeutic Potential of Psychedelic-assisted Therapies for Symptom Control in Patients Diagnosed With Serious Illness: A Systematic Review
Lucas de Oliveira Maia, Yvan Beaussant, Ana Cláudia Mesquita Garcia
Medicine
CINAHL
PsycINFO
DOI: 10.1016/j.jns.2022.120302
2022
Cited 4 times
Review of otential sychedelic reatments for PTSD
Ryan L. Henner, Matcheri S. Keshavan, Kevin D. Hill
MDMA
Context (archaeology)
Psilocybin
DOI: 10.1016/j.neubiorev.2022.104724
2022
Cited 3 times
Don’t be afraid, try to meditate- potential effects on neural activity and connectivity of psilocybin-assisted mindfulness-based intervention for social anxiety disorder: A systematic review
Corinna L. Felsch, Kim P.C. Kuypers
Psilocybin
Mindfulness
Psychology
DOI: 10.1021/acschemneuro.2c00461
2022
Skepticism about Recent Evidence That Psilocybin “Liberates” Depressed Minds
Manoj K. Doss, Frederick S. Barrett, Philip R Corlett
Psilocybin
Psychology
Ambiguity
DOI: 10.1007/s00213-022-06187-5
2022
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world
Rosalind Watts, Hannes Kettner, Dana Geerts, Sam Gandy, Laura Kartner, Lea Mertens, Christopher Timmermann, Matthew M. Nour, Mendel Kaelen, David Nutt, Robin Carhart-Harris, Leor Roseman
Social connectedness
Psychology
Scale (ratio)
DOI: 10.1007/s11864-022-00954-4
2022
Depression and Long-Term Prescription Opioid Use and Opioid Use Disorder: Implications for Pain Management in Cancer
Nicole Bates, Jennifer K. Bello, Nosayaba Osazuwa-Peters, Mark Sullivan, Jeffrey F. Scherrer
Medicine
Duloxetine
Venlafaxine
DOI: 10.17992/lbl.2022.09.706
2022
The use of psilocybin for treatment-resistant depression
Arny Johannesdottir, Engilbert Sigurdsson
Psilocybin
Hallucinogen
Treatment-resistant depression
DOI: 10.1016/j.psychres.2022.114727
2022
Magic Mushrooms – an exploratory look at how mental health professionals feel and think about Psilocybin
Thomas J. Meyer, Priel Meir, Claudia Lex, Jair C. Soares
Psilocybin
Psychology
Hallucinogen
DOI: 10.1128/aem.01498-22
2022
DNA Authentication and Chemical Analysis of <i>Psilocybe</i> Mushrooms Reveal Widespread Misdeterminations in Fungaria and Inconsistencies in Metabolites
Alexander J Bradshaw, Talia A Backman, Virginia Ramírez-Cruz, Dale L Forrister, Jaclyn M Winter, Laura Guzmán-Dávalos, Giuliana Furci, Paul Stamets, Bryn T M Dentinger
Psilocybin
Biology
Pharmacology
DOI: 10.1093/milmed/usac095
2022
Is PTSD an Evolutionary Survival Adaptation Initiated by Unrestrained Cytokine Signaling and Maintained by Epigenetic Change?
Stephan Rudzki
Epigenetics
Immune system
Cytokine
DOI: 10.7759/cureus.25414
2022
Unraveling the Mysteries of Mental Illness With Psilocybin
Robert Sotille, Herpreet Singh, Anne Weisman, Thomas Vida
Psilocybin
Hallucinogen
Medicine
DOI: 10.3389/fphar.2022.927984
2022
Three Naturally-Occurring Psychedelics and Their Significance in the Treatment of Mental Health Disorders
Nataliya Vorobyeva, Alena A. Kozlova
Psilocybin
Anxiety
Psychiatry
DOI: 10.1002/jcad.12429
2022
Counselors’ attitudes toward psychedelics and their use in therapy
Benjamin G. Hearn, Michael D. Brubaker, George Richardson
Psilocybin
MDMA
The Renaissance
DOI: 10.1016/j.cct.2022.106976
2022
Psilocybin for alcohol use disorder: Rationale and design considerations for a randomized controlled trial
Kelley C. O'Donnell, Sarah E. Mennenga, Lindsey Owens, Samantha K. Podrebarac, Tara Baron, John Rotrosen, Stephen Ross, Alyssa A. Forcehimes, Michael P. Bogenschutz
Psilocybin
Medicine
Randomized controlled trial
DOI: 10.1556/2054.2022.00214
2022
Psilocybin use patterns and perception of risk among a cohort of Black individuals with Opioid Use Disorder
John M. Clifton, Annabelle M. Belcher, Aaron D. Greenblatt, Christopher Welsh, Thomas B. Cole, Alan T. Davis
Psilocybin
Psychiatry
Methadone
DOI: 10.3389/fpsyt.2022.883869
2022
Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees
Maggie Kiraga, Kim P. C. Kuypers, Malin V Uthaug, Johannes G. Ramaekers, Natasha L. Mason
Psilocybin
Anxiety
Psychology
DOI: 10.1227/neu.0000000000002275
2022
Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology
Daniel F. Kelly, Keith Heinzerling, Akanksha Sharma, Shanthi Gowrinathan, Karina Sergi, Regin Jay Mallari
Psilocybin
Medicine
Mood